Rubin Lab

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Clinical trials of new and emerging therapies potentially offer the patient a more effective treatment. Much is happening in basic, translational and clinical research for IBD. Our clinicians interact closely with immunologists, microbiologists, geneticists, pathologists and other scientists at the University of Chicago who are working in the field of digestive diseases. Current studies are looking at the many genes associated with IBD and the role of intestinal microflora in contributing to the disorder. Whatever the area of research, we all have the same goals: to develop better and more specific treatments for IBD and ultimately to prevent and cure the disease.

Tandem Therapy Using Cyclosporine and Tofacitinib for the Treatment of Severe Ulcerative Colitis

This case study looked at the combination of Cyclosporine and Tofacitinib. This patient remained in clinical remission at the 17-month follow-up.

Admission Risk Factors as Predictors of In-Hospital Colectomy in Acute Severe Ulcerative Colitis

This study aimed to identify early predictors of colectomy to improve medical therapies.

Early identification of potential medically refractory disease has the potential to reduce need for colectomy in acute severe ulcerative colitis.

Ulceration of the Pre-Pouch Ileum in Patients with Ulcerative Colitis Following Proctocolectomy with Ileal Pouch-Anal Anastomosis: An Analysis of Pouchoscopies from 272 Patients.

This study aimed to describe the prevalence and contributing factors of pre-pouch ileal ulcerations in a cohort of patients undergoing pouchoscopies.

Development of a Novel Web-based Yoga, Breathing and Meditation Site for Patients with Inflammatory Bowel Disease.

This study aimed to explore the impact of yoga, meditation and breathing techniques on symptomatic and non-symptomatic IBD patients.

Increased Prevalence of Sinusitis Among Patients with Inflammatory Bowel Disease

This study aimed to establish incidence and prevalence of sinusitis as reported in patients with IBD and assess epiphenomenon between sinusitis and IBD.

Female sex, black/African-American race, bowel obstruction, and steroid use was associated with a diagnosis of sinusitis associated with IBD, but no directionality in sinusitis diagnosis in IBD was identified.